Can quarterback Matthew Stafford and the Los Angeles Rams repeat as champs?
ESPN's Monday Night Football opener is Sept. 12 and will feature Russell Wilson's debut with the Denver Broncos hosting his former team, the Seattle Seahawks.
Based on strength of schedule -- which is determined by opponents' records in 2021
the Rams have the toughest schedule of the 2022 season and the Dallas Cowboys and Washington Commanders tie for the easiest.
The NFL expanded to 17 regular-season games last season.
The final regular-season games for the 2022 season will be played Jan. 8, 2023